Leaving Against Therapeutic Advice (often called Leaving Against Medical Advice, or AMA) occurs when a patient chooses to leave a healthcare facility before the treating clinician recommends discharge. This situation presents complex ethical challenges and reflects broader systemic, social, and interpersonal problems within healthcare delivery. Leaving Against Therapeutic Advice is not merely an individual patient choice but a multifaceted ethical and systemic challenge. While patient autonomy must be respected, healthcare providers have an ethical responsibility to ensure informed decision-making, effective communication, and compassionate care. Addressing the underlying social, economic, and institutional factors—along with strengthening patient-provider relationships—can help reduce the incidence of leaving against advice and improve overall health outcomes.